Genesis subtheme for Drupal
Download/install genesis folder to sites/all/themes
Move genesis_subtheme folder up one level so it's also at sites/all/themes
Change name of subtheme folder to name of your choice.
In subtheme folder, change subtheme names accordingly for .info and .css files.
In the .info file, change references to genesis_subtheme to the new custom theme name.
Choose layout (two column, three column, etc). They layouts are described in the layout.css file in the original genesis folder, with an id number for each layout. Then modify the page.tpl.php in the subtheme folder to reference the layout that you'd like to use.
Choose width. The subtheme css file has an entry for overall width of the page around line 58.